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Retatrutide works in the treatment of obesity by targeting three different hunger regulating hormones:
- GIP (gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide) is an incretin hormone that is released from the gut after eating. It stimulates the beta-cells in the pancreas to secrete insulin.
- GLP-1 (glucagon-like peptide-1) is also an incretin hormone that stimulates the beta-cells to secrete insulin.
- glucagon is a hormone secreted from the alpha-cells in the pancreas. It stimulates glucose production
The drug has been nicknamed 'triple G' because it is an agonist of all three receptors.
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